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Hello visitor from
USA - 45 visiting from 25 USA 7 Canada 4 France 2 Germany 1 Hong Kong 1 Cambodia 1 UK 1 Ukraine 1 China 1 Australia 1 Brazil
Donepezil Ep, Usp
Posted at: Offers to Sell and Export | Posted on: Wednesday 10 July 2013 7:09 am | Poster last visit: Monday 5 August 2013 |
Product Description:
Applications
Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic
use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks. Donepezil is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that donepezil alters the course of the underlying dementing process.
Company Contact:
Contact Name: Yanjie Wang
Company Name: Hopeland Chem-tech Co., Ltd
Email:
Tel: +86 29 6296 0726
Fax: +86 29 6296 0725
Street Address: 4th Gaoxin Road
Xian, Shaanxi 710075
China
Member name: Hopeland
Country: China
Member Since: 24 June 2013
Total Leads: 62 Hopeland Import Export Business Leads
Business focus: Packing Machine, Feeding Additives, Processing Machinery
Chat:
Verify: Safe Import Export Tips
Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic
use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It is well absorbed in the gut with an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a half life of about 70 hours, it can be taken once a day. Initial dose is 5 mg per day, which can be increased to 10 mg per day after an adjustment period of at least 4 weeks. Donepezil is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that donepezil alters the course of the underlying dementing process.
Company Contact:
Contact Name: Yanjie Wang
Company Name: Hopeland Chem-tech Co., Ltd
Email:
Tel: +86 29 6296 0726
Fax: +86 29 6296 0725
Street Address: 4th Gaoxin Road
Xian, Shaanxi 710075
China
Member name: Hopeland
Country:
ChinaMember Since: 24 June 2013
Total Leads: 62 Hopeland Import Export Business Leads
Business focus: Packing Machine, Feeding Additives, Processing Machinery
Chat:
Verify: Safe Import Export Tips
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